Evaluation of Urate Urolithiasis Recurrence in Dalmatians Consuming Royal Canin Veterinary Diet Urinary U/C ™ 18
Purpose of Study
Urate urolithiasis is a common disease in many Dalmatians due to a defect in uric acid metabolism. Prevention strategies for the management of urate stones in the Dalmatian have been suggested and include low protein diets, bicarbonate supplementation, xanthine oxidase inhibitors, and increased water intake but no data exists as to the efficacy of any of these recommendations. Protein restricted diets are often prescribed for Dalmatians with urate stones to decrease the purine load and uric acid excretion. The typical diet prescribed for this disease contains only 9-13% protein on a metabolizable energy (ME) basis and no studies have been published regarding this diet’s efficacy.
Because prolonged protein restriction could lead to unwanted side effects, a newer diet has been launched by Royal Canin. This diet contains almost twice as much protein (19% ME) as the standard prescription diet and has been reported to be very palatable. Therefore, the goals of this study are to evaluate the efficacy of this diet over a one year time period in Dalmatians with a history of urate urolithiasis by performing imaging studies, urinalyses and relative supersaturation studies for urate. Furthermore, we will screen for protein malnutrition by determining serum albumin, protein and plasma amino acid concentrations as well as each dog’s body composition using body condition scoring and deuterium oxide (D2O) analysis. All diagnostic testing and diet for one year is FREE!